Which of the following which of the following is needed to synthesize a new strand of DNA. There are four basic components required to initiate and propagate DNA synthesis. These are there are four basic components required to initiate and propagate their DNA synthesis. They are substrate number one second. They are template 3rd. There are primary and four There are enzymes. So and RNA primer and arrival. Samel. An RNA primer is needed to begin DNA synthesis. A new strand is. RNA primer is needed to begin begin their DNA synthesis.