Original DNA Sequence:
mRNA Sequence:
Amino Acid Sequence:
Mutated DNA Sequence # 5 TACACCTTGGGACGACT...
What's the mRNA sequence?
What will be the amino acid sequence?
Will there likely be effects?
1. Which type of mutation is responsible for new variations of a trait?
2. Which type of mutation does not result in an abnormal amino acid sequence?
3. Which type of mutation stops the translation of an mRNA molecule?
Sickle Cell Anemia
TACACCTTGGCGACGACT...
Normal hemoglobin DNA
82
Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin molecule.
Hemoglobin carries oxygen in your red bloods cells. The mutation causes these red blood cells to become stiff &
sickle-shaped when they release their oxygen. The sickled cells tend to get stuck in blood vessels, causing pain and
increased risk of stroke, blindness, damage to the heart & lungs, and other conditions.
- Analyze the DNA strands below to determine what amino acid is changed AND what type of mutation occurred
Normal hemoglobin mRNA
Normal hemoglobin AA sequence
Sickle cell hemoglobin DNA
What type of mutation is this?
Sickle cell hemoglobin mRNA
Sickle cell hemoglobin AA sequence
CACGTAGACTGAGGACTC...
CACGTAGACTGAGGACAC...
(Circle the change)
4. What type of mutation is this? Please explain why.