A 43-year-old female presents with several years of pain and stiffness in her wrists and hands. Her symptoms have been getting progressively worse. She reports that her hands feel stiff for an hour or more after awaking in the morning. She undergoes subsequent testing, and is found to have anti-citrullinated protein antibodies. Her physician is concerned for rheumatoid arthritis, and discusses treatment with a biologic disease-modifying anti-rheumatic agent. Which of the following must be done before beginning treatment with a TNF inhibitor?
A. Confirm diagnosis with a test for rheumatoid factor
B. Confirm diagnosis with elevated ESR and CRP
C. Test for latent mycobacterial infection
D. Obtain a radiograph demonstrating osteophytes
E. Obtain an exercise stress test