A 25yearold pregnant woman comes for genetic counseling. Her screening results are positive for an increased risk for SmithLemliOpitz (SLO) syndrome. Her results are as follows:

AFP = 1.00 MoM
HCG = 0.95 MoM
UE3 = 0.10 MoM
INH = 1.10 MoM

In addition to counseling the woman about SLO, which of the following should be discussed?
A. steroid sulfatase deficiency
B. trisomy 21
C. biotinidase deficiency D. trisomy 18