Respuesta :
It could affect a protein a few different ways:
1. If you get a switch of one nucleotide for another, this could (but not always) result in a different amino acid being inserted than was supposed to. So, for example, you were supposed to insert a methionine at AUG of the mRNA, but the mutation resulted in GUG which now codes for valine. This may disrupt the activity in the protein - either in proper folding or if in the active site of an enzyme could disrupt the activity.
2. Other swaps of nucleotides can result in shortened proteins - so if you were supposed to have tyrosine inserted at UAU and that got switched to UAA which is a stop codon, then the protein is too short - and may not fold or function correctly. Depends where the mutation is of course.
3. Of course take that further and perhaps you were supposed to have a stop codon (UAA) and that got switched to UAU...so now instead of stopping the protein synthesis you instead insert a tyrosine and the protein continues to be extended until another stop codon is reached...that could be disastrous for the function of the protein as it probably won't fold properly.
1. If you get a switch of one nucleotide for another, this could (but not always) result in a different amino acid being inserted than was supposed to. So, for example, you were supposed to insert a methionine at AUG of the mRNA, but the mutation resulted in GUG which now codes for valine. This may disrupt the activity in the protein - either in proper folding or if in the active site of an enzyme could disrupt the activity.
2. Other swaps of nucleotides can result in shortened proteins - so if you were supposed to have tyrosine inserted at UAU and that got switched to UAA which is a stop codon, then the protein is too short - and may not fold or function correctly. Depends where the mutation is of course.
3. Of course take that further and perhaps you were supposed to have a stop codon (UAA) and that got switched to UAU...so now instead of stopping the protein synthesis you instead insert a tyrosine and the protein continues to be extended until another stop codon is reached...that could be disastrous for the function of the protein as it probably won't fold properly.
