Proteins are made by the ribosomes either free in the cytoplasm (soluble proteins) or docked on the endoplasmic reticulum, after a small amount is initially translated in the cytoplasm (proteins that are destined to be secreted out of the cell, incorporated into the plasma membrane, retained in the endoplasmic reticulum or Golgi complex. Proteins that traverse through the endoplasmic reticulum are further modified in the endoplasmic reticulum and Golgi complex.
