A drug that decreases gastrointestinal motility would be one that A. decreases contraction in smooth muscle.
What reasons clean muscle contraction?
Smooth muscle contraction is initiated whilst the Ca++ binds to intracellular calmodulin, which then turns on an enzyme referred to as myosin kinase that phosphorylates myosin heads on the way to shape the cross-bridges with actin after which pull on the skinny filaments.
- Drugs including adrenoceptor agonists, muscarinic agonists, nitrates, and calcium channel blockers all have an effect on clean muscle. Hormones also can have an effect on clean muscle function.
- Dephosphorylation of myosin mild chains terminates clean muscle contraction. Unlike skeletal muscle, clean muscle is phosphorylated for the duration of its activation, which creates a capacity issue in that certainly lowering calcium stages will now no longer produce muscle relaxation.
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