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What is the role of pH in the maintenance of DNA inside a nucleus? How can pH be disrupted?

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Answer:

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Hydrogen ions play a central role in the lives of cells. For example, changes in hydrogen ion concentration are intimately tied to the charge of side chains in proteins. This charge state, in turn, affects the activity of enzymes as well as their folding and even localization. Further, the famed ATP synthases that churn out the ATPs that power many cellular processes are driven by gradients in hydrogen ions across membranes.

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