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Prior to the advent of multiplex genetic testing, a person would have been most likely to have a genetic test to determine if they had an increased risk of which of the following? Prior to the advent of multiplex genetic testing, a person would have been most likely to have a genetic test to determine if they had an increased risk of which of the following? pancreatic cancer lung cancer thyroid cancer colon cancer

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Answer: Colon cancer

Explanation:

All cancers, but especially colon and rectal cancers, commonly referred to as colorectal cancer (CRC), have hereditary factors that potentially increase one’s risk.

Genetic testing is determine if there is an increased risk of colon cancer. Apolipoprotein E (apoE) plays a major role in the metabolism of bile acids, cholesterol and triglycerides, and has recently been proposed as being involved in the carcinogenic process. Given the potential role of bile acids in colorectal cancer etiology, it is reasonable that colorectal cancer risk might be modified by apoE genotype. The absence of an e3 apoE allele significantly increased the risk of colon cancer especially for individuals above 50years.

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