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Mannitol is a drug that temporarily disrupts tight junctions. This drug is often added to medications that need to get into the extra-cellular fluid of the brain because it will make the capillaries of the ________ more permeable to larger molecules.

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Answer is

body-brain barrier.

Explanation:

Mannitol injection is used to reduce swelling ande pressure around the brain.

It enhances flow of water from tissues including cerebrospinal fluid and the brain into plasma and interstitial fluid.

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