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Giacomo has used methamphetamines for a while. To feel the effects of the drug, he now has to take more of it than he used to, which means that Giacomo is experiencing __________.

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eyesightlll
Giacomo is experiencing tolerance of methamphetamines.

Since Giacomo has been taking methamphetamines for a while, he has built up tolerance of the drug, causing him to take more to feel the effects.