Answer:
1) The genetic changes can lead to a reduction in the capacity of the mice to move glycogen at its branches points and lowers blood glucose levels between meals.
2) Genetic changed can lead to a decrease in the capacity to lower blood glucose due to the knock out of the hexokinase gene leading to elevated levels in the bloodstream.
(c) A knockout of FBPase2 will result in elevated levels of fructose-2,6-bisphosphate in
liver favoring the glycolytic pathway and inhibiting gluconeogenesis by the decrease of fructose 1,6-
bisphosphatase-1 activity
(d) An active FBPase-2 will now favor gluconeogenesis and this inhibits glycolysis. I.e. a decrease in PFK-1 activity while increasing FBPase-1 activity simultaneously.
