Which of the following statements is NOT true regarding the role of myosins in muscle contraction? Calcium release from the sarcoplasmic reticulum induces muscle contraction by changing the conformation of actin-binding proteins, allowing myosin binding. Unipolarity of the thick filaments is crucial for ATP hydrolysis to result in sarcomere contraction. Mutations in myosin heavy chain genes can cause hypertrophic cardiomyopathy. Myosin II has a very low duty ratio.