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Homologous recombination can repair double-strand breaks without any change in DNA sequence, but nonhomologous end joining always involves a loss of genetic information because the ends are degraded by nucleases before they can be ligated back together.

True or False?

Respuesta :

The statement is true.

Explanation:

The homologous and the non homologous repair of the chromosomes are the events that take place in cases of DNA damage. The damaged DNA can be repaired by two means, one is by taking the help of the DNA from homologous chromosome which is done in homologous DNA repair, other by directly ligating the ends of broken DNA taking the help of micro homologies which are hanging part of single stranded DNA from broken DNA. The second process is often accompanied by action of nuclease which breaks some of the nucleotides to shape the DNA. This results to unnecessary mutations, the hallmarks of Tumour cell.