A DNA mutation changes the shape of the extracellular domain of transmembrane receptor protein A produced by the cell. Which of the following predictions is the most likely consequence of the mutation? (Figure)

a. The molecule that normally binds to protein AA will no longer attach, deactivating the cellular response.
b. The glucocorticoid receptor will remain associated with the accessory proteins.
c. The intracellular concentration of glycogen will increase.
d. The SRYSRY gene produces a protein that binds to specific regions of DNADNA in certain tissues, which affects the development of these tissues.

The extracellular domain of the transmembrane receptor protein acts as binding site for primary messenger molecule whereas the transmembrane domain holds the receptor within membrane and the cytosolic domain has intrinsic tyrosine kinase activity, all these helps in proper cell signaling

If because of any mutation there is change in shape of the extracellular domain then that molecule that normally binds to the receptor protein will no longer attach hence cellular response will be deactivated

luisvaschetto luisvaschetto · Answer 2 · 2021-10-09T15:29:38+02:00

The transmembrane proteins are integral membrane proteins that totally span biological membranes. These proteins function on both sides of the lipid bilayer and/or transport molecules across it.

The statement "The molecule that normally binds to protein AA will no longer attach, deactivating the cellular response." represents the most likely consequence of this mutation (Option a).

In this case, the transmembrane protein is a receptor that binds by an extracellular domain to its substrate (i.e., the protein AA).

Thus, the extracellular domain of this transmembrane protein contains a binding domain whose active site interacts with the protein AA.

A mutation capable of modifying the tridimensional (3D) shape of the binding site of the protein will alter its binding to the substrate, thereby it is expected that the transmembrane protein cannot interact with the protein AA.

In consequence, the signaling pathway induced by ligand-binding cannot be activated.

In conclusion, the statement "The molecule that normally binds to protein AA will no longer attach, deactivating the cellular response." represents the most likely consequence of this mutation (Option a).

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