The phrase “the danger is in the dose” means that sometimes it contains toxic chemicals too.
The inorganic chemicals most commonly responsible for poisonings in the United States are cyanide, mercury, arsenic, and lead. While the last three often appear in chemical forms that are quite harmless, it is the soluble salts of the substances that are poisons. Cyanide is a dangerous substance in any form. Overdoses can happen at many opioid dose levels. For example, for instance if a patient drinks alcohol while on the medications, loses track of when they last took a dose, or takes more than the prescribed dose to handle a flare-up of pain.
Thus, we can say overdose can be the danger in the dose.
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