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#4: unbound to plasma proteins
To produce therapeutic or toxic effects, drugs interact with receptors in the body the pharmacodynamic phase of drug action. The drug in the tissues, where drug-receptor interactions usually occur, is in equilibrium with the unbound drug in the plasma.
To produce therapeutic or toxic effects, drugs interact with receptors in the body the pharmacodynamic phase of drug action. The drug in the tissues, where drug-receptor interactions usually occur, is in equilibrium with the unbound drug in the plasma.
A drug that is unbound to plasma proteins can produce a therapeutic response.
What is a therapeutic response?
A therapeutic response is a desired effect that is gotten from the administration of drug which is beneficial to the treatment of diseases.
The therapeutic response of a drug is hindered when it binds to the plasma protein. This is because:
- it increases the molecular weight of the drug, and
- prevents it from binding to the drug target site.
Therefore, a drug that is unbound to plasma proteins can produce a therapeutic response.
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