In animals, if the fuel consumed exceeds energy expended, fats are synthesized from carbohydrates in order to store the excess energy. Acetyl-coA Carboxylase catalyzes the first dedicated step in fatty acid synthesis. This enzyme responds to a large number of cellular signals. A logical strategy for the regulation of Acetyl-coA Carboxylase might include:

at the time when the AMP concentration is high because it represent the energy is deficit in the cell while on the other hand the lower AMP versus ATP concentration represent that the surplus energy i.e. stored

So ACC enzyme could be activated

Therefore the option b is correct

luisvaschetto luisvaschetto · Answer 2 · 2021-11-16T12:10:59+01:00

A logical strategy for the regulation of Acetyl-coA Carboxylase might include the activation when the concentration of AMP is low versus the concentration of ATP.

Acetyl-CoA carboxylase (ACC) is an enzyme that catalyzes the carboxylation of acetyl-CoA in order to produce malonyl-CoA. The hydrolysis of ATP generates the energy required to drive this reaction.

This molecule (malonyl-CoA) is an intermediate substrate required for the regulation of fatty acid metabolism.

AMP-activated protein kinase (AMPK) is a fuel-sensing enzyme found in mammalian cells, which is required to phosphorylate the ACC protein.

This enzyme (AMPK) acts as a fuel gauge because it is activated by AMP and inhibited by ATP.

In conclusion, a logical strategy for the regulation of Acetyl-coA Carboxylase might include the activation when the concentration of AMP is low versus the concentration of ATP.

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