Skepticism played a major role during the Renaissance, both before and after the rediscovery of Sextus Empiricus’ works and the revival of Pyrrhonism. In its various branches, this philosophical movement connected with various orientations, bringing forth new combinations that, albeit somehow eclectic, revealed its fecundity and strength of innovation. It connected with fideism (Gianfrancesco Pico), rhetoric and dialectic (Talon), occultism and Neoplatonism (H. C. Agrippa), empiricism (Montaigne), Stoicism (Charron), and epistemology and metaphysics (Sanches and Campanella). Skepticism acted as a factor of moderation in theological debates (Erasmus, Castellion) and had an important impact on seventeenth-century philosophy, until Campanella, Descartes, and Hobbes.