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The first step in the replication of DNA is catalyzed by _____. ligase single-strand binding protein primase DNA polymerase helicase

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Answer: The answer is helicase. This enzyme allows of the unzipping of the double helix DNA to form the replicating fork. They use ATP hydrolysis to break the hydrogen bonds between nucleotide bases. This comes before binding, on the DNA, by replication enzymes such as DNA Polymerase III.  

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