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It will shift the reading frame by one base, altering how DNA is translated because it is read as codons (triplets of bases). Single base insertions or deletions are most influential near the beginning of a gene.

The genetic code is of utmost importance as a slight change in it can change the characteristics of an organism. Just like that base insertion or deletion can cause shifting of frame and can result in a change of the nucleotide sequence causing mutation.

What are the types of mutation?

Mutation is any change in the genetic sequence that can lead to changes in the genome.

It can be of the following types:

  • Germline mutation: In gametes, germline mutations occur. Other cells in the body experience somatic mutations.
  • Chromosomal alterations: these are mutations that change the structure of the chromosome.
  • Point mutations: it affects only one nucleotide.
  • Frameshift mutations: these are nucleotide additions or deletions that cause a shift in the reading frame.

Thus, base insertion or deletion likely to drastically change how the rest of the genetic code is read as it result in frameshift mutation.

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