Based on what we know, we can confirm that a very acidic or basic change to the pH would most likely cause death to aliens that have similar enzymes to the mammals on Earth.
This has to do with the role of enzymes in the body. Enzymes are catalysts for just about all of the reactions that take place in the bodies of mammals. These enzymes that are essential for life, are very vulnerable to strong changes in pH, which cause them to denature and lose functionality.
Therefore, we can confirm that a very acidic or basic change to the pH would most likely cause death to aliens that have similar enzymes to the mammals on Earth.
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