The evidence from the text that helps with the inference is that lady Macbeth is convinced that she sees the blood of Duncan's and Banquo's families on her hands.
What is an inference?
This is known as a conclusion reached on the basis of evidence.
Hence, we can see that from the complete story, Lady Macbeth's conversations with the doctor shows an evidence of her feeling guilty of the killings going with her words "The Thane of Fife had a wife; where is she now? What, will these hands ne'er be clean?"
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