Of the four globins that make up hemoglobin, two are identical and called alpha globins, and the other two are called beta globins and are also identical.
Structure of Haemoglobin
- Each of the four subunits of hemoglobin has a polypeptide chain and a heme group.
- The iron protoporphyrin IX prosthetic heme group, which is connected to a polypeptide chain with residues of 141 (alpha) and 146 (beta) amino acids, is present in all hemoglobins.
- A histidine's N is linked to the ferrous iron of the heme. A polypeptide chain phenylalanine of the porphyrin ring wedges it into its pocket.
- Alpha and beta chains, two varieties of the polypeptide chains that make up adult hemoglobin, are comparable in length but have different amino acid sequences.
- Both adult and embryonic human hemoglobins have the same alpha chain.
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