The morphologic abnormality characteristically found in hemoglobinopathies is codocytes.
Red blood cells called codocytes, also called target cells, resemble a shooting target with a bullseye.
The codocyte is a bell-shaped cell that is located in vivo (inside the blood vessel). It only adopts a "target" configuration when a blood film is desired.
Artifact: Target cell development happens when blood smears are performed under humid conditions.
Hemoglobinopathies: Increased surface area to volume ratio and unequal hemoglobin dispersion within the cell.
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