If inhibiting thyroid hormone release with PTU (propylthiouracil) in an experiment, the experimental group receives PTU and the control group receives no PTU.
What is propylthiouracil (PTU) used for?
- The thyroid gland's ability to produce fresh thyroid hormone is inhibited by the drug propylthiouracil.
- It works by preventing the thyroid peroxidase enzyme from doing its normal job of converting iodide to an iodine molecule and incorporating that molecule into the amino acid tyrosine.
- PTU prevents iodine and peroxidase from forming T4 and T3 from reacting normally with thyroglobulin.
- Thyroid hormone synthesis is decreased by this action.
- Because T3 is more effective than T4 and PTU prevents T4 from being converted to T3, thyroid hormone activity is also decreased.
- An important factor in controlling body temperature is thyroid hormone.
- The body must rely more on shivering to regulate temperature in the absence of thyroid hormone.
- To generate ATP, additional oxygen must be used.
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