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A paternally imprinted gene called p57(Kip2) encodes a powerful inhibitor of a number of cyclin/Cdk complexes.
What is p57(Kip2) ?
A paternally imprinted gene called p57(Kip2) encodes a powerful inhibitor of a number of cyclin/Cdk complexes. The expression of p57(Kip2), which connects with G1 Cdks and can cause cell cycle arrest in G1 phase, is typically found in terminally differentiated cells. We eliminated the p57(Kip2) gene by homologous recombination in ES cells and created animals devoid of p57(Kip2) expression to study the function of p57(Kip2) in vivo. The majority of p57(Kip2) null mice are born dead and have severe developmental abnormalities that can range in penetrance. Heterozygous mice inheriting a mother targeted allele but not a paternal allele show identical deficits and neonatal mortality, as expected. Cleft palates and gastrointestinal abnormalities ranging from an enlarged GI tract to the deletion of the jejunum and ileum are among the developmental problems of p57(Kip2) mutant mice.
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