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Thrombosis is a clear risk when any foreign material is in contact with the bloodstream.
What are the significance of Thrombosis ?
Thrombosis is a well-known side effect of introducing foreign materials into the bloodstream, such as those found in medical devices such as stents, valves, and intravascular catheters. Despite numerous published research, the body's response to foreign elements in contact with the blood remains unknown. Drug-eluting coatings on devices or systemic injection of conventional anticoagulants are currently used as prophylactic measures. We offer a putative method by which surface chemistry can influence fibrinogen structure, hence influencing platelet adherence and, as a result, thrombus development. Our findings point to a potential covering that promotes endothelial cell attachment while inhibiting platelet adherence.
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