Respuesta :

The de novo cholesterol synthesis begins with the production of acetyl CoA through the acetate or citrate.

Acetyl CoA is then transformed into the 3-hydroxy-3-methylglutaryl-CoA (HMG CoA), mevalonate, squalene, lanosterol, and cholesterol through cholesterol several enzymatic transformations.

What is Cholesterol is generated ?

  • Cholesterol is generated from acetyl-CoA through a complex multistep process.
  • This multi-step process involves the 3-hydroxy-methylglutaryl-CoA reductase (HMG-CoA-R).
  • This helps to mediate the rate-limiting step catalyzing the conversion of HMG-CoA to mevalonic acid.

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