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Ere is a mutation in a bacterial gene x's promoter that changes a nucleotide from a t to an a in a postition between the -10 and -35 elements. what does this mutation do (most likely)?

Respuesta :

The ere mutation plays an important role in Breast Cancer.

What is the role of ere mutation in Breast cancer?

  • The backbone of therapy for estrogen receptor-positive bosom tumors, endocrine treatment impressively brings down bosom malignant growth-related mortality and sickness recurrence.
  • The atomic chemical receptor family incorporates the estrogen receptor (ER), which capabilities as a ligand-enacted record factor.
  • A conformational change in the receptor is achieved by the communication of the ligand.
  • The receptor then moves to the core, joins as a homodimer to explicit DNA groupings known as estrogen reaction components (ERE), and controls the record of a few objective genes.
  • The ER's space configuration comprises a pivot space that partitions the ligand-restricting area from the DNA-restricting area, a profoundly monitored DNA-restricting area that intercedes specific acknowledgment of ERE, and an N-terminal chemical free transactivation area (AF1).

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