[Association between the 5-HTTLPR Polymorphism of Serotonin Transporter Gene and EEG in Young and Postmenopausal Women] pdf

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10-08-2022
Biology

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[Association between the 5-HTTLPR Polymorphism of Serotonin Transporter Gene and EEG in Young and Postmenopausal Women] pdf

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sonalideval056 sonalideval056 · Answer 1 · 2022-08-19T13:29:26+02:00

These findings show that the polymorphism of 5-HTTLPR is associated with different neurophysiological mechanisms of age-related alterations in brain activity.

Polymorphism:

The regulating effect of serotonin transporter gene polymorphisms on female brain activity may change with age-related hormonal changes, according to the influence of ovarian steroids on serotonin neurotransmission.
The goal of the study was to find connections between baseline EEG features and the serotonin transporter gene's 5-HTTLPR polymorphism in healthy young women (19-35 years, N = 85) and postmenopausal women (55-80 years, N = 44).
The older age group of women who were L'/L' (LA/LA) and S'/S' (SA/SA, SA/LG) genotype carriers showed lower delta, alpha 2, and alpha 3 band power than the younger group. When compared to S'/L' genotype, carriers of the S'/S' and L'/L' genotypes had lower values for the power of these rhythms in older women. Higher beta 1 rhythm power in elderly women than in young women was a trait associated with the S'/L' genotype.
These findings show that the polymorphism of 5-HTTLPR is associated with different neurophysiological mechanisms of age-related alterations in brain activity.

Learn more about polymorphism here brainly.com/question/20317264

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