nonsyndromicMutation in PDS gene are Known to be responsible for both pendered syndrome and non syndromic hearing loss.
Some children affect from Pendered Syndrome are totally . Almost all children with Pendered Syndrome can be bilateral hearing loss , which means hearing loss in both ears .One ear can have more hearing loss than the other . The symptoms of this loss can be goitre , speech impairment , deafness and enlarged vestibular aqueduct .
PDS mutation analysis confirm that PDS mutations were present and responsible for 90% Pendered families ,some families with nonsyndromic hearing loss with enlarged vestibular aqueduct .
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