Respuesta :

Based on these data, dendritic cells activated in the presence of 1,25(OH)2D3 are likely to show reduced MHC class II and reduced B7 expression compared to controls.

Indeed, DCs matured in the presence of 1,25(OH)2D3 showed a capacity to activate alloreactive CD4+ cell as low as that of immature DCs.

There are three stages during T cells activation by DCs, namely antigen presenting, antigen recognition of T cells and two signals formation. In addition, IS formation between T cells and DCs also play an important role.

Dendritic cells can stimulate the development of autoreactive T cells as well as generate immunological tolerance.

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