Respuesta :
To evaluate the intestinal flora in PCOS and investigate the potential role of abnormal intestinal flora in insulin resistance and the development of PCOS, as well as the potential role of chenodeoxycholic acid (CDCA) in activating the intestinal farnesoid X receptor (FXR) and enhancing PCOS glucose metabolism.
Setting & design:
- Both hormonally healthy controls and treatment-naive PCOS patients had their gut flora examined.
- On a letrozole-induced PCOS mouse model, phenotype analysis, intestinal flora analysis, and global metabolomic profiling of caecal contents were done.
- Comparable studies were also done after 35 days of antibiotic treatment and after 35 days of CDCA treatment on the PCOS mouse model.
- After 10 weeks, mice that had received fecal microbiota transplantation from PCOS patients or healthy controls were assessed.
What results can be observed?
- Patients with PCOS who had never received therapy had considerably more Bacteroides.
- The PCOS mouse model replicated the Bacteroides enrichment.
- Removing the gut microbiota improved insulin resistance and the PCOS phenotype while also raising relative FXR mRNA levels in the ileum and serum fibroblast growth factor 15 levels.
- At 10 weeks, mice with PCOS stool transplants showed insulin resistance but not PCOS.
- The PCOS mouse model's glucose metabolism was enhanced by CDCA treatment.
What can be concluded?
- A crucial microbiological indicator for PCOS, Bacteroides has diagnostic relevance.
- Insulin resistance may be a result of gut dysbiosis.
- In PCOS, glucose metabolism may be improved rather than worsened by FXR activation.
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