If the active site of an enzyme is damaged, leaving it nonfunctional, the reaction proceeds as if it were a non-catalyzed reaction without a lowering of the activation energy.
What is the active site of an enzyme?
An active site of an enzyme is the site in an enzyme which the substrate molecules binds to in order for the enzyme to perform its function.
The effective binding of substrate to active site of an enzyme enables catalysis to occur.
Thus, when the active site of an enzyme is damaged, the enzyme becomes non-functional.
Based on the graph, the reaction proceeds as if it were a non-catalyzed reaction without a lowering of the activation energy as seen in the purple colored graph.
In conclusion, effective bonding of substrate to enzyme active site is essential for catalysis to occur.
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