Respuesta :
Upon 5-aminolevulinic acid (5-ALA) injection, around 20 percent low-grade gliomas (LGG) show detectable protoporphyrin fluorescence following surgery.
What is Aminolevulinic Acid-Induced Fluorescence?
5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is an efficient surgical adjuvant for intraoperative tumor tissue identification during high-grade glioma resection
Some characteristics of Aminolevulinic Acid-Induced Fluorescence are-
- In glioblastoma (GBM), 5-ALA-induced PpIX fluorescence has been found to increase the extent of gross-total clearance and six month progression-free survival.
- When using this instrument intraoperatively, this heterogeneity in 5-ALA-induced PpIX fluorescence poses a technical and diagnostic barrier.
- While certain areas of the tumor glow brightly following 5-ALA treatment, others do not, despite the fact that both areas of the tumour could be histopathologically indistinguishable.
- Using computational approaches, the authors investigated the basis in biology of this heterogeneity.
To know more about the Aminolevulinate dehydratase (ALAD), here
https://brainly.com/question/13596620
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