Decarboxylation is then used to transform this into the parent mononucleotide uridine 5′-monophosphate (UMP), which serves as the building block for all other pyrimidine nucleotides.
Phosphoribosyl diphosphate
hypoxanthine-xanthine-guanine phosphoribosyl transferase
Orotate phosphoribosyl transferase
Purine nucleoside phosphorylase
Purines are produced either through de novo synthesis or through consumption of substances that contain purines. Pyrimidines are created when the essential nucleotide substrate uridine 5′-monophosphate is combined with carbamylphosphate and aspartate to create orotic acid (UMP).
Two major purines present in nucleotides are adenine (A) and guanine (G), and three major pyrimidines are thymine (T), cytosine (C), and uracil (U).
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