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Chemicals from the skin's outer surface are transported into the skin and into the bloodstream through skin absorption. The degree of exposure to and potential consequences of a drug that might enter the body through the skin are discussed in relation to skin absorption.

What is absorption?

  • Substances can enter the body through the skin through a process called skin absorption.
  • Dermal absorption is a method of medicine administration as well as a route of exposure for harmful compounds, along with inhalation, ingestion, and injection.
  • The concentration of a substance, the length of contact, the solubility of the medication, the physical state of the skin and the exposed area of the body, and other factors all affect how well a substance is absorbed through the skin.
  • Chemicals from the skin's outer surface are transported through the skin (percutaneously or dermally) and into the bloodstream.
  • Skin absorption is concerned with the extent of exposure and potential consequences of a drug that might enter the body through the skin.

What pathways are there for absorption through the skin?

  • Through penetration (8-2), permeation (8-3: intercellular routes and 8-4: hair shaft route), and resorption, substances or particles are absorbed by the skin (8-5).
  • A substance enters the body through the skin layers by penetration.

Learn more about absorption here:

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