Long-term use of one drug increases tolerance to different drugs because these compounds need to bind the same receptors for to produce a given effect.
The expression drug tolerance makes reference to higher concentrations of drugs required to produce the same effect due to the rate between a drug and its receptors in the cell.
This phenomenon (drug tolerance) is associated with the increase of the concentration of a given drug to produce the same effect due to the ligand-receptor relationships between both variables.
Different drugs use the same receptors in the cell to bind and trigger a given signaling pathway, thereby one drug may increase the tolerance of another substance.
In conclusion, long-term use of one drug increases tolerance to different drugs because these compounds need to bind the same receptors for to produce a given effect.
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