Targeting the proteins in the plasma membrane does not require the drug taken up into the cell.
The cell membrane or plasma membrane is the outer covering of the cell. It is selectively permeable which does not allow every molecule to pass through it. It only allows some selective organic molecules to enter or exit through it. It, therefore, does not allow medications to pass thorough it or alter its chemical composition. Rather the medications target the proteins there to allow their functioning.
Plasma membrane proteins transmit the signals into the cell and catalyze reactions. The chemical composition of a drug is altered by the plasma membrane and a more acceptable form is produced to facilitate absorption by the desired organ. It also performs the distribution of drugs to various organs to produce the desired therapeutic effect.
Because not all drugs or medications are natural or organic molecules, they can't enter the cell. Therefore, any medication or drug targets the proteins in the plasma membrane.
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