Free radicals damage cells by destroying phospholipids in the cell membrane.
An eukaryotic cell is separated from the extra-cellular environment by the cell membrane which is composed of phospholipid bilayer. This cell membrane is selectively permeable. Loss or damage to this layer can lead to compromised cellular homeostasis and death of the cell.
Hypoxic injury results in an inadequate flow of nutrients and oxygen to the cell. If tissue perfusion continues to be insufficient, hypoxia occurs and the cell turns to anaerobic metabolic pathways for production of energy. Hypoxic cell damage can induce both necrosis and apoptosis.
Therefore, free radicals damage cells by destroying phospholipids in the cell membrane.
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