The Barr body (named after its discoverer, Murray Barr) or X chromatin, contains multiple X chromosomes that are transformed in a process called lyonization in species with XY sex determination (including humans).
Inactive X chromosome in cells with The Lyon hypothesis states that in cells with multiple X chromosomes, all but one are inactivated during mammalian embryogenesis. This happens by chance early in mammalian embryonic development , but in some extraembryonic mammals in marsupials and some placental mammals where the sperm X chromosome is always inactivated. Excluding tissue. , XX) has one Barr body per somatic nucleus, whereas genotype male (46, XY) has none. Barr bodies can be seen in interphase nuclei as dark blobs in contact with the nuclear envelope. Barr bodies are found in neutrophils at the edge of the nucleus.
In a person with multiple X chromosomes, the number of Barr bodies visible at interphase is always one less than her total number of X chromosomes. For example, people with Klinefelter syndrome (47,XXX) have one Barr body, and people with a karyotype of 47,XXX have two Barr bodies.
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