Mast cells help regulate other types of immune responses as well as how the immune system reacts to certain germs and parasites. They include substances including growth factors, cytokines, heparin, and histamine.
Macrophages play a crucial role in the upkeep and defence of host tissues by detecting and swallowing foreign particles and, when necessary, triggering an inflammatory reaction. Almost all tissues they migrate to and circulate through as they search for infections or remove dead cells
Mast cells are linked to the development of tumours, and angiogenesis and cancer cell motility have been seen to be induced by macrophages. Macrophages generate inflammatory cytokines similar to mast cells.
At the location of the cut, they produce substances that widen blood vessels.
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