Jasonschmirler5892 Jasonschmirler5892

12-09-2022
Biology

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Which loss of function would occur if you introduced a chemical that functioned as an inhibitor of the ryanodine receptor channel?

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tutorconsortium31 tutorconsortium31

14-09-2022

Myosin would not be able to bind to actin in order to cause shortening of the sarcomere.

What is ryanodine receptor ?

In both cardiac and skeletal muscle, ryanodine receptors (RyRs), which are found in the sarcoplasmic/endoplasmic reticulum membrane, are in charge of releasing Ca2+ from intracellular reserves during excitation-contraction coupling.

Millimolar doses of caffeine activate RyRs. RyR sensitivity to Ca2+ increases noticeably (from micromolar to picomolar) in the presence of high (more than 5 mmol/L) caffeine concentrations, making baseline Ca2+ concentrations activatory.

Learn more about Receptors here:

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