many mutations in receptor kinases that lead to cancer allow the receptor to dimerize and become activated, even in the absence of signaling molecules. an example is a mutant form of the egf receptor kinase called her2/neu. an antibody that prevents dimerization of her2/neu receptor kinases is being tested for its effectiveness in preventing cancer. at which stage does this drug work?

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10-12-2022
Medicine

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many mutations in receptor kinases that lead to cancer allow the receptor to dimerize and become activated, even in the absence of signaling molecules. an example is a mutant form of the egf receptor kinase called her2/neu. an antibody that prevents dimerization of her2/neu receptor kinases is being tested for its effectiveness in preventing cancer. at which stage does this drug work?

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kjuli1766 kjuli1766 · Answer 1 · 2022-12-19T11:56:29+01:00

An antibody that prevents dimerization of Her2/neu receptor kinases would prevent the receptor from becoming activated.

A protein involved in normal cell growth. HER2/neu may be produced in excess by some types of cancer cells, such as breast, ovarian, bladder, pancreatic, stomach, and esophageal cancers. This can cause cancer cells to grow faster and spread to other parts of the body. Checking her HER2/neu levels in some types of cancer cells can help plan treatment. Also called c-erbB-2, HER2, human EGF receptor 2, human epidermal growth factor receptor 2.

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