In recent years, modern technology has made great strides in the fight against malaria, including the development of vaccines and insecticides to reduce the spread of the disease.
However, if technology were to completely eradicate malaria but not alleviate sickle-cell disease, the sickle-cell allele frequency in subsequent generations would likely remain unchanged.
Sickle-cell disease is a genetic disorder caused by a mutation in the hemoglobin gene, which affects red blood cells. This mutation causes the red blood cells to become misshapen and can lead to a range of serious health complications. The allele responsible for the disorder is inherited and is more common in certain areas where malaria is more prevalent, such as Sub-Saharan Africa. It is thought that this allele is maintained in these populations because it confers a degree of protection against malaria.
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