When a nucleotide is removed from a DNA sequence, this is called a deletion mutation. Deletion mutations often cause a frameshift, which shifts the reading frame and can result in a completely different set of codons for the resulting mRNA and a significantly altered amino acid sequence.
As seen in this example, a deletion mutation that causes a frameshift can lead to a completely different mRNA sequence and a significantly altered amino acid sequence, potentially resulting in significant changes to the structure and function of the resulting protein.
