It is necessary that the neurotransmitter molecule is eliminated after each stimulation event. its removal can occur by (1) , in which the neurotransmitter is chemically in the and (2) , in which the neurotransmitter is reabsorbed by a neurotransmitter in the membrane of the neuron. these neurotransmitters are "recycled" once packaged into another synaptic vesicle for reuse.

This normal synaptic homeostasis allows for the recycling of neurotransmitters and regulates the level of neurotransmitter present in the synapse, thereby controlling how long a signal resulting from neurotransmitter release lasts. This is important before another impulse can be transmitted across the synapse.

Answer Link

andriansp andriansp · Answer 2 · 2018-04-19T08:49:39+02:00

1. It is necessary that the neurotransmitter molecule is eliminated after each stimulation event. Its removal can occur by degradation, in which the neurotransmitter is chemically inactivated in the synaptic cleft and

A neurotransmitter that released by the neuron will keep spread in the synaptic cleft and excite the receptor if not eliminated. One of the methods is to degrade/destroy the neurotransmitter chemically so it will not be able to bind to the receptor again. The example would be acetylcholine esterase which will degrade acetylcholine

(2) reuptake, in which the neurotransmitter is reabsorbed by a neurotransmitter transport protein in the membrane of the presynaptic neuron. These neurotransmitters are "recycled" by the presynaptic neuron once packaged into another synaptic vesicle for reuse.

Another method to eliminate the neurotransmitter is by reuptake. This method involves and active transport which done by the protein in the membrane of the presynaptic neuron. The neurotransmitter in the cleft is taken back so it could be reused later.
One of the transmitters that use this method is serotonin. Depression drug will inhibit the reuptake so there is more serotonin released in the brain.