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What is the role of the nuclear localization sequence in a nuclear protein? select one:
a. it is bound by cytoplasmic proteins that direct the nuclear protein to the nuclear pore.
b. it is a hydrophobic sequence that enables the protein to enter the nuclear membranes.
c. it aids in protein unfolding so that the protein can thread through nuclear pores.
d. it prevents the protein from diffusing out of the nucleus through nuclear pores?

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BioWizard
The correct answer is a. it is bound by cytoplasmic proteins that direct the nuclear protein to the nuclear pore.  

This sequence (NLS) serves to protein for import into the cell nucleus via nuclear transport. During the nuclear transport protein with an NLS will bind strongly to importin and together this complex will move through the nuclear pore into the nucleus.

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