Gram-negative bacteria can create resistance by changing its hydrophobic properties or by creating mutation . Gram-positive bacteria lack this properties, which makes Gram-negative bacteria more resistant to antibiotics than Gram-positive ones.
Gram-negative bacteria have a unique outer membrane. This outer membrane stops certain drugs and antibiotics from entering the cell, partially the reason why gram-negative bacteria are generally more resistant to antibiotics than are gram-positive bacteria.
Gram-positive bacteria, are the species with peptidoglycan outer layers, these thick peptidoglycan layer absorbs antibiotics and cleaning products easily. In contrast, their are many membraned species resist this intrusion with their multi-layered structure.
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